Usage Simulation

In non-human primate testing, BZH-811 caused vesodilation, pupil dilation, increased heart rate and increased frontal lobe activity that lasted for between 5 and 9 days depending on the dose. Obviously the psychotropic dissociative and eleriant effects cannot be measured in animals, so the trails proceeded to primary human testing.

A student volunteer was recruited under the prevert of testing FDA approved hallucinogen controlled substances. He professed to have substantial exploitance with recreational used of hallucinogens (Ref Form # 3456AL).

The subject was interred in a sealed ward at Dixmor and allowed a day and night to allow him to habituate to his surroundings before the dose was administered. One doctor and one orderly were to be on watch at all times throughout the course of the experiment. They were briefed to be unobtrusive yet talkative and to offer any assistance the subject requested. It was important to try and keep the subject talking throughout to better gauge the effects of the compound.

00.30 Subject began to report waves of visual sensation and euphoria. When asked to describe what he was experiencing in more detail, he expressed that the experience was pleasurable. The visual hallucinations were concurrent with over stimulation of dopamine receptors as witnessed from neuro-imaging during non-human primate trails of BZH-811.

01:30 Subject appeared to have lost ego integrity and was unable to recall his own name. Time and space appeared to be alien concepts to him, effects often reported in recreational users of ayahuasca. He began to react to imagined external stimuli, such as ducking suddenly for no reason and dancing to imagined music. He was clearly having a positive experience and made repeated attempts to get the staff to join him in consuming the compound.

03:15 After almost 2 hours of positive frame of mind, the subject suddenly stopped moving and expressed paranoid delusions of persaction, which he then forgot almost instantly. The psychotomimentic effects and memory dysfunction are symptoms often associated with inhibition of NMDA receptors, a common effect of ingesting phencyclidine.

04:00 Further bouts of negative feelings are expressed with increasing frequency. The subject has started to become less responsive to unobtrusive questioning and all movement ceases during these negative phases.

04:30 Subject expressed the desire to stop the experience. Staff informed the subject that this was not possible and the subject became agitated and threatened staff with physical violence.

05:00 Bouts of negativity persist, but the subject is generally positive. Some level of mental regression appears to have taken place with the subject using childish turns of phase and referring to a staff member as "pop". Subject has lost control of his bowels.

06:45 After a prolonged bout of negativity, the subject jumped to his feet and smashed his head into a window sill. Staff forcibly restrained the subject and returned him to a chair and remained in close proximity. When questioned as to the sudden outburst, the subject has no recollection. He complained of a headache.

07:30 After a period of (difficult to read) calm (difficult to read) , the subject again made a sudden self-injury this time by smashing his head against a wall. Severe laceration was made on the subjects forehead, resulting in profuse bleeding down the subjects face. The subject screamed in anguish and claimed to have gone blind. The blood (difficult to read) from his eyes and the patient calmed down. Questioning revealed that the subject was stuck in some sort of sensory overload. Subject reports a load (difficult to read) noise which he described as like a thousand angry bees trying to force their way into my head through my ear that was getting louder and louder. He was also able to smell burning flesh and this smell was also getting stronger

07:40 As soon as questioning had finished the subject used his own head to strike an (difficult to read). The decision was taken to temporally restrain the subject for the safety of the staff.

08:00 Subject has eventually been restrained on a bed, but the restraints had a bad effect on his state of mind. Subject continually screams at loud volume.

09:30 Subject has not yet ceased screaming at full volume. The decision has been taken to continue the experiment despite the possible damage to his vocal cords.

10:00 High volume screaming continues. The subject has started to strain against (difficult to read) him down. Blood vessels appear to have burst on both sides of his forehead (difficult to read) evidence of blood seepage in the middle ear the subject was determined to have burst his own eardrums with the noise of his screams.

10:15 Screaming continues and the subject has managed to (difficult to read) against the supports with such force that there are cuts across his chest area and (difficult to read) have then instructed to place the subject in a straight jacket and (difficult to read) cell.

10:45 Subject has been installed in the padded cell. His (difficult to read) has not yet abated, but his voice is becoming increasingly horse and can barely (difficult to read) heard outside the cell. Subject is moving slowly round the walls of his cell.

11:15 (difficult to read) speed of the subject's movement around the cell have increased steadily to the point that he may be at risk of harming himself.

11:25 Subject has loosened the straps on the straight jacket somehow and has removed it. Arms flail at his sides as his continue to bounce off the walls. He apparently is attempting to scream but no noise is coming out at all. His face is now almost completely red with burst blood vessels.

11:35 Subject has stopped moving and is lying motionless in the middle of his cell.

11:45 Blood haemorrhaging visible as Staff enter the cell

11:50 Subject declared deceased.