Experimental subjects had a range of burns inflicted
while under aesthetic from intravenous- Meperidine injections. The trial
burn-repair salve was then applied to allow analysis of the salve's tissue
repair ability. After two days the aesthetic was withdrawn to enable observation
of the pain reliving effects of the salve. Results were mixed and further
trials are recommended. Future trials should proceed without the supplementary
anaesthetics to avoid the fatalities caused by hypoperfusion in phase
three. |
6 male subjects were selected with no significant
health issues with 6 different degrees of burns to test, a subject was
assigned at random to each burn class, and assigned an indent (#01, #06).
Subject’s bodies were divided into test regions for treatment of
each limb serving as a separate test region. Each subject was restrained
and anesthetized prior to infliction of burns. For subjects #01 and #02
a metal bar was heated and then applied to the skin for varying amounts
of time. For subjects #03 through #06, a blowtorch was used.
Administering first and second degree burns proved simple
infliction of third degree burns was significantly harder as the subject
was clearly able to feel significant pain despite the aesthetic. Forth
and fifth degree burns were more straight forward due to the extent of
burning, which quickly destroyed the nerves leading to inhibited pain
sensation. Sixth degree burns characterized by charred bone tissue, proved
the most problematic. On the first occasion, the sixth degree test subject
suffered emesis due to the smell of burnt bones and despite out best efforts,
we were not able to the remove the gag in time and the emesis entered
his trachea causing asphyxiation. A substitute was quickly brought forward
and the trails continued. Each subject has 4 burns introduced. |
With each subject divides into, test regions, varying
amounts of experimental salve were applied to each region. 5mg were applied
to the left arm, 10mg to the left leg, 20mg to the right leg and 40mg
to the left arm of each subject. Fresh applications were made every 6
hours.
In summery, any amount of salve over 5mg was sufficient
to cause 92% tissue repair for the first degree burns. 20mg and over caused
87% tissue repair in the second degree subjects. Almost no repair was
witnessed in the subjects with third degree burns and above. |
To evaluate the pain relieve effects of the salve,
the aesthesia was withdrawn 48 hours after the test of the trail. First
and second degree burn subjects had largely recovered by this time and
the salve added sufficient analgesic effects so that they expressed little
to no discomfort. The subject with third degree burns gradually began
to express increasing discomfort, including lots of screaming, crying
and shouting abuse at staff. Interestingly, the subject with fourth degree
burns had skin irretrievably damaged, took longer to express pain than
the one with third degree burns presumably due to extensive nerve damage.
The firth degree subject’s reaction was more dramatic. The subject expressed severe pain within 30 minutes of the withdrawal of the aesthetic. He quickly fell into a coma from which he had not woken, 2 hours after the procedure. The subject with sixth degree burns, reacted adversely to the withdrawal suffering hypoperfusion within 15 minutes. He was declared dead shortly afterwards through hypoxia. |